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Completely, our data provide proof for your probable of mixing CX-5461 and PARPi for improving upon the remedy of HR-deficient HGSOC. We display that CX-5461 enhances the synthetic lethal interaction of PARPi with HRD and Plainly display that CX-5461 has a different mechanism of action to PARPi. Importantly, we characterized BRCA-mutated and MYC ta